The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses.
Type I interferon is a key player in innate immunity and in the activation of effective adaptive immune responses. From: Encyclopedia of Virology (Third Edition) ...
由 LC Platanias 著作 · 2005 · 被引用 3857 次 — All type I interferons (IFNs) bind a common receptor at the surface of human cells, which is known as the type I IFN receptor. The type I IFN ...
由 LB Ivashkiv 著作 · 2014 · 被引用 3225 次 — Type I interferons (IFNs) are polypeptides that are secreted by infected cells and have three major functions. First, they induce cell-intrinsic antimicrobial ...
由 AJ Lee 著作 · 2018 · 被引用 616 次 — Type I IFN is a well-known stimulator of antiviral genes targeted against preventing virus replication from within target cells. When their production is ...
由 G Schreiber 著作 · 2020 · 被引用 121 次 — Type I interferon receptors are found on all cell types, and are a major component of the innate immune system. Human type I interferons include 13 similar ...
由 CML de Padilla 著作 · 2016 · 被引用 156 次 — Historically, IFNs have been classified into two major types, type I and type II, based on their interactions with the IFN receptor subunits, peptide mapping, ...
由 F McNab 著作 · 2015 · 被引用 2382 次 — Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, ...